Malaria has a negative impact on health and social and economic life of residents of endemic countries. The ultimate goals of\r\ndesigning new treatment for malaria are to prevent clinical infection, reduce morbidity, and decrease mortality. There are great\r\nadvances in the understanding of the parasite-host interaction through studies by various scientists. In some of these studies,\r\nattempts weremade to evaluate the roles ofmalaria pigment or toxins in the pathogenesis of malaria. Hemozoin is a key metabolite\r\nassociated with severe malaria anemia (SMA), immunosuppression, and cytokine dysfunction. Targeting of this pigment may be\r\nnecessary in the design of new therapeutic products against malaria. In this review, the roles of hemozoin in the morbidity and\r\nmortality of malaria are highlighted as an essential target in the quest for effective control of clinical malaria.
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